Inhibition of p70S6K does not mimic the enhancement of Akt phosphorylation by rapamycin
It has been suggested that the mTOR complex 1 (mTORC1)/p70S6K axis represses upstream PI3K/Akt signaling through phosphorylation of IRS-1 and its subsequent degradation.One potential and current model that explains Akt activation induced caruso milk thistle by the mTOR inhibitor rapamycin is the relief of mTORC1/p70S6K-mediated feedback inhibition